Osmium absorption after osmium tetroxide skin and eye exposure

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10412652" target="_blank" >RIV/00216208:11110/20:10412652 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/20:43920207 RIV/00064190:_____/20:N0000057 RIV/00064165:_____/20:10412652 RIV/71009396:_____/20:N0000004
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1MP0zQQFh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1MP0zQQFh</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcpt.13450" target="_blank" >10.1111/bcpt.13450</a>

Result language
angličtina
Original language name
Osmium absorption after osmium tetroxide skin and eye exposure
Original language description
Osmium tetroxide is a strong oxidizing agent used in electron microscopy. Eye exposure may cause severe burns, and after inhalation or ingestion damage to the respiratory or gastrointestinal tract occurs. Exposure to osmium and its compounds is extremely rare. We present a case of a 32-year-old female stained by 9 mL of 2% osmium tetroxide in acetone during an accident in the laboratory, with rare dermal and ocular findings. Due to lack of data in toxicological databases and the absence of antidote, the therapy was symptomatic. Osmium was detected in serum 19 hours later (0.22 mu g/L) and in urine during the 15-hour collection (three samples-7.05, 1.65 and 8.45 mu g/L). In blood serum on admission, after 1 and 2 days after exposure, the levels of iron (28.2, 39.8 and 50.5 mu mol/L; reference range 5.8-34.5 mu mol/L) and transferrin receptor/ferritine were elevated. To our knowledge, this is the first paper documenting a significant absorption from the skin and potentially from the eye conjunctiva, based on serum and urine analysis. The relationship between increased iron in blood and exposure has not been described yet, and the mechanism remains unknown. The patient is being followed up for the unknown long-term effects.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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