Pheochromocytoma With Adrenergic Biochemical Phenotype Shows Decreased GLP-1 Secretion and Impaired Glucose Tolerance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10413148" target="_blank" >RIV/00216208:11110/20:10413148 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/20:43920026 RIV/00064173:_____/20:N0000170 RIV/00023001:_____/20:00079646 RIV/00064165:_____/20:10413148

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HW7APGbS1z" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HW7APGbS1z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1210/clinem/dgaa154" target="_blank" >10.1210/clinem/dgaa154</a>

Result language

angličtina

Original language name

Pheochromocytoma With Adrenergic Biochemical Phenotype Shows Decreased GLP-1 Secretion and Impaired Glucose Tolerance

Original language description

Context: Impaired glucose homeostasis is a common finding in pheochromocytoma (PHEO), especially with adrenergic phenotype. The possible contribution of incretin dysfunction to dysglycemia in PHEO patients has not been studied. Objective: To compare changes in pancreatic endocrine function and gut hormones&apos; production during a liquid meal test before and 1 year after adrenalectomy. Methods: In a prospective study, we included 18 patients with PHEO (13 females) with adrenergic biochemical phenotype. A liquid meal test with predefined isocaloric enteral nutrition was performed to evaluate dynamic changes in pancreatic hormones and incretins. Results: During the meal test, insulin levels were significantly lower before adrenalectomy only in the early phase of insulin secretion, but changes in area under the curve (AUC) did not reach statistical significance (AUC = 0.07). Plasma glucagon (AUC &lt; 0.01) and pancreatic polypeptide levels (AUC &lt; 0.01) were suppressed in comparison with the postoperative state. Impaired response to the meal was found preoperatively for glucagon-like peptide-1 (GLP-1; AUC P &lt; 0.05), but not glucose-dependent insulinotropic polypepide (GIP; AUC P = 0.21). No significant changes in insulin resistance indices were found, except for the homeostatic model assessment-beta index, an indicator of the function of islet p cells, which negatively correlated with plasma metanephrine (R =-0.66, P &lt; 0.01). Conclusions: Our study shows suppression of pancreatic a and 13 cell function and impaired GLP-1 secretion during a dynamic meal test in patients with PHEO, which is improved after its surgical treatment. These data demonstrate a novel and potentially significant interconnection between excessive catecholamine production and the secretion of glucoregulatory hormones.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NV16-30345A" target="_blank" >NV16-30345A: Pheochromocytoma as a model of chronic activation of the stress axis in the pathogenesis of metabolic disorders</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The Journal of Clinical Endocrinology &amp; Metabolism

ISSN

0021-972X

e-ISSN

—

Volume of the periodical

105

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

1878-1887

UT code for WoS article

000553452200048

EID of the result in the Scopus database

2-s2.0-85086093948