An optical coherence tomography comparison of coronary arterial plaque calcification in patients with end-stage renal disease and diabetes mellitus
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10417838" target="_blank" >RIV/00216208:11110/20:10417838 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/20:10417838
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=DB4eI20z4F" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=DB4eI20z4F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1479164120958425" target="_blank" >10.1177/1479164120958425</a>
Alternative languages
Result language
angličtina
Original language name
An optical coherence tomography comparison of coronary arterial plaque calcification in patients with end-stage renal disease and diabetes mellitus
Original language description
Background: Coronary arterial plaques in patients with end-stage renal disease (ESRD) are assumed to have increased calcification due to underlying renal disease or initiation of dialysis. This relationship may be confounded by comorbid type 2 diabetes mellitus (DM). Methods: From a single-center OCT registry, 60 patients were analyzed. Twenty patients with ESRD and diabetes (ESRD-DM) were compared to 2 groups of non-ESRD patients: 20 with and 20 without diabetes. In each patient, one 20 mm segment within the culprit vessel was analyzed. Results: ESRD-DM patients exhibited similar calcium burden, arc, and area compared to patients with diabetes alone. When compared to patients without diabetes, patients with diabetes exhibited a greater summed area of calcium (DM: Median 9.0, IQR [5.3-28] mm(2) vs Non-DM: 3.5 [0.1-14] mm(2), p = 0.04) and larger calcium deposits by arc (DM: Mean 45 +/- SE 6.2 degrees vs Non-DM: 21 +/- 6.2 degrees, p = 0.01) and area (DM: 0.58 +/- 0.10 mm(2) vs Non-DM: 0.26 +/- 0.10 mm(2), p = 0.03). Calcification deposits in ESRD-DM patients (0.14 +/- 0.02 mm) and patients with diabetes (0.14 +/- 0.02 mm) were more superficially located relative to patients without diabetes (0.21 +/- 0.02 mm), p = 0.01 for both. Conclusions: Coronary calcification in DM and ESRD-DM groups exhibited similar burden, deposit size, and depth within the arterial wall. The increase in coronary calcification and cardiovascular disease events seen in ESRD-DM patients may not be secondary to ESRD and dialysis, but instead due to a combination of declining renal function and diabetes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV16-28525A" target="_blank" >NV16-28525A: Assessment of functional significance of coronary artery disease with focus on lesion morphology and genetic polymorphisms</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetes & Vascular Disease Research
ISSN
1479-1641
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
1479164120958425
UT code for WoS article
000587489400006
EID of the result in the Scopus database
2-s2.0-85091811931