The weak association between neurofilament levels at multiple sclerosis onset and cognitive performance after 9 years
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10420425" target="_blank" >RIV/00216208:11110/20:10420425 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/20:10420425
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=BuXRBfSOHX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=BuXRBfSOHX</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.msard.2020.102534" target="_blank" >10.1016/j.msard.2020.102534</a>
Alternative languages
Result language
angličtina
Original language name
The weak association between neurofilament levels at multiple sclerosis onset and cognitive performance after 9 years
Original language description
Background: Neurofilament light chain level in serum (sNfL) and cerebrospinal fluid (CSF-NfL) is a promising biomarker of disease activity in multiple sclerosis (MS). However, predictive value of neurofilaments for development of cognitive decline over long-term follow-up has not been extensively studied. Objective: To investigate the relationship between early neurofilament levels and cognitive performance after 9 years. Methods: We included 58 MS patients from the SET study. sNfL levels were measured at screening, at 1 and 2 years. CSF-NfL were measured in 36 patients at screening. Cognitive performance was assessed by the Brief International Cognitive Assessment for Multiple Sclerosis and the Paced Auditory Serial Addition Test-3 s at baseline, at 1, 2 and 9 years. Association between neurofilament levels and cognition was analyzed using Spearmans correlation, logistic regression and mixed models. Results: We did not observe associations among early sNfL levels and cross-sectional or longitudinal cognitive measures, except of a trend for association between higher sNfL levels at screening and lower California Verbal Learning Test-II (CVLT-II) scores at year 1 (rho=-0.31, unadjusted p = 0.028). Higher sNfL level was not associated with increased risk of cognitive decline, except of a trend for greater risk of CVLT-II decrease in patients with higher sNfL levels at 1 year (OR=15.8; 95% CI=1.7-147.0; unadjusted p = 0.015). Similar trends were observed for CSF-NfL. Conclusion: We found only weak association between sNfL levels at disease onset and evolution of cognitive performance over long-term follow-up.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NV18-08-00062" target="_blank" >NV18-08-00062: Quantitative multiparametric MRI for longitudinal monitoring of multiple sclerosis: correlation with clinical status and biochemical markers</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Multiple Sclerosis and Related Disorders
ISSN
2211-0348
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
November
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
102534
UT code for WoS article
000597310700024
EID of the result in the Scopus database
2-s2.0-85092181638