Value of cord blood Treg population properties and function-associated characteristics for predicting allergy development in childhood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10424686" target="_blank" >RIV/00216208:11110/20:10424686 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/20:10424686

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-btDte.1lN" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-btDte.1lN</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/ceji.2020.103413" target="_blank" >10.5114/ceji.2020.103413</a>

Result language

angličtina

Original language name

Value of cord blood Treg population properties and function-associated characteristics for predicting allergy development in childhood

Original language description

Allergic diseases represent some of the most common immunological disorders with high clinical and economic impact. Despite intensive research, there are still few universally accepted and reliable biomarkers capable of predicting their development at an early age. There is therefore a pressing need for identification of potential predictive factors and validation of their prognostic value by correlating them with allergy development. Dysbalance of the branches of immune response, most often excessive Th2 polarization, is the principal cause of allergic diseases. Regulatory T cells (Treg) are a crucial population for the timely establishment of physiological immune polarization and induction and maintenance of tolerance against environmental antigens. This makes them a potentially promising candidate for an early marker predicting allergy development. In our study, we analysed samples of cord blood of children of allergic mothers and children of healthy mothers by flow cytometry and retrospectively correlated the data with clinical allergy status of the children at the age of 6 to 10 years. Studied parameters included cord blood Treg population proportions and functional properties - intracellular presence of IL-10 and TGF-b, MFI of FoxP3. We observed higher percentage of Tregs in cord blood of children who did not develop allergy compared with allergic children. Further, we found higher numbers of IL-10+ Tregs in cord blood of healthy children of healthy mothers than in cord blood of children of allergic mothers and decreased TGF-b+ cord blood Tregs in the group of allergic children of allergic mothers compared to all other groups.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/NV15-26877A" target="_blank" >NV15-26877A: Effect of early postnatal colonisation of newborns by E. coli on allergy incidence, selected immunological characteristics and microbiota composition</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central-European Journal of Immunology

ISSN

1426-3912

e-ISSN

—

Volume of the periodical

45

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

10

Pages from-to

393-402

UT code for WoS article

000639537000003

EID of the result in the Scopus database

2-s2.0-85104382230