All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Induction of fecal cholesterol excretion is not effective for the treatment of hyperbilirubinemia in Gunn rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10411288" target="_blank" >RIV/00216208:11110/21:10411288 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064165:_____/21:10411288

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5nOWSM4f9U" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5nOWSM4f9U</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41390-020-0926-2" target="_blank" >10.1038/s41390-020-0926-2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Induction of fecal cholesterol excretion is not effective for the treatment of hyperbilirubinemia in Gunn rats

  • Original language description

    Background: Unconjugated hyperbilirubinemia, a feature of neonatal jaundice or Crigler-Najjar syndrome, can lead to neurotoxicity and even death. We previously demonstrated that unconjugated bilirubin (UCB) can be eliminated via transintestinal excretion in Gunn rats, a model of unconjugated hyperbilirubinemia, and that this is stimulated by enhancing fecal fatty acid excretion. Since transintestinal excretion also occurs for cholesterol (TICE), we hypothesized that increasing fecal cholesterol excretion and/or TICE could also enhance fecal UCB disposal and subsequently lower plasma UCB concentrations. Methods: To determine whether increasing fecal cholesterol excretion could ameliorate unconjugated hyperbilirubinemia, we treated hyperbilirubinemic Gunn rats with ezetimibe (EZE), an intestinal cholesterol absorption inhibitor, and/or a liver X receptor (LXR) and farnesoid X receptor (FXR) agonist (T0901317 (T09) and obeticholic acid (OCA), respectively), known to stimulate TICE. Results: We found that EZE treatment alone or in combination with T09 or OCA increased fecal cholesterol disposal but did not lower plasma UCB levels. Conclusions: These findings do not support a link between the regulation of transintestinal excretion of cholesterol and bilirubin. Furthermore, induction of fecal cholesterol excretion is not a potential therapy for unconjugated hyperbilirubinemia. Impact: Increasing fecal cholesterol excretion is not effective to treat unconjugated hyperbilirubinemia. / This is the first time a potential relation between transintestinal excretion of cholesterol and unconjugated bilirubin is investigated. / Transintestinal excretion of cholesterol and unconjugated bilirubin do not seem to be quantitatively linked. / Unlike intestinal fatty acids, cholesterol cannot &quot;capture&quot; unconjugated bilirubin to increase its excretion. / These results add to our understanding of ways to improve and factors regulating unconjugated bilirubin disposal in hyperbilirubinemic conditions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pediatric Research

  • ISSN

    0031-3998

  • e-ISSN

  • Volume of the periodical

    89

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    510-517

  • UT code for WoS article

    000530593000001

  • EID of the result in the Scopus database

    2-s2.0-85084244306