Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10192311" target="_blank" >RIV/00216208:11110/13:10192311 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1158/1940-6207.CAPR-13-0125" target="_blank" >http://dx.doi.org/10.1158/1940-6207.CAPR-13-0125</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1158/1940-6207.CAPR-13-0125" target="_blank" >10.1158/1940-6207.CAPR-13-0125</a>
Alternative languages
Result language
angličtina
Original language name
Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models
Original language description
The bile pigment bilirubin is a known antioxidant and is associated with protection from cancer and cardiovascular disease (CVD) when present in too strong concentrations. Unconjugated bilirubin (UCB) might also possess anti-genotoxic potential by preventing oxidative damage to DNA. Moderately elevated bilirubin levels are found in individuals with Gilbert syndrome and more severe in the hyperbilirubinemic Gunn rat model. This study was therefore aimed to assess the levels of oxidative damage to DNA inGilbert syndrome subjects and Gunn rats compared tomatched controls. Seventy-six individuals (age- and sex-matched) were allocated into Gilbert syndrome (UCB }= 17.1 mu mol/L; n - 38) or control groups (UCB < 17.1 mu mol/L; n = 38). In addition, 40 Gunnrats were used to support the results of the human trial. Single-cell gel electrophoresis (SCGE) assay measuring standard conditions (strand breaks, apurinic/apyrimidinic sites) and formamidopyrimidine glycosylase (FPG)-sensitive sites wa
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Prevention Research
ISSN
1940-6207
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1056-1063
UT code for WoS article
000325272400007
EID of the result in the Scopus database
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