Tumour-free distance: a novel prognostic marker in patients with early-stage cervical cancer treated by primary surgery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10425722" target="_blank" >RIV/00216208:11110/21:10425722 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/21:10425722 RIV/00216224:14110/21:00120906

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-zZnXDiaSS" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-zZnXDiaSS</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41416-020-01204-w" target="_blank" >10.1038/s41416-020-01204-w</a>

Result language

angličtina

Original language name

Tumour-free distance: a novel prognostic marker in patients with early-stage cervical cancer treated by primary surgery

Original language description

Background: Models predicting recurrence risk (RR) of cervical cancer are used to tailor adjuvant treatment after radical surgery. The goal of our study was to compare available prognostic factors and to develop a prognostic model that would be easy to standardise and use in routine clinical practice. Methods: All consecutive patients with early-stage cervical cancer treated by primary surgery in a single referral centre (01/2007-12/2016) were eligible if assessed by standardised protocols for pre-operative imaging and pathology. Fifteen prognostic markers were evaluated in 379 patients, out of which 320 lymph node (LN)-negative. Results: The best predictive model for the whole cohort entailed a combination of tumour-free distance (TFD) &lt;= 3.5 mm and LN positivity, which separated two subgroups with a substantially distinct RR 36% and 6.5%, respectively. In LN-negative patients, a combination of TFD &lt;= 3.5 mm and adenosquamous tumour type separated a group of nine patients with RR 33% from the rest of the group with 6% RR. Conclusions: A newly identified prognostic marker, TFD, surpassed all traditional tumour-related markers in the RR assessment. Predictive models combining TFD, which can be easily accessed on pre-operative imaging, with LN status or tumour type can be used in daily practice and can help to identify patients with the highest RR.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30214 - Obstetrics and gynaecology

Project

<a href="/en/project/NV19-03-00023" target="_blank" >NV19-03-00023: A prospective observational trial on sentinel lymph node biopsy in patients with early stage cervical cancer – Part 2</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Cancer

ISSN

0007-0920

e-ISSN

—

Volume of the periodical

124

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1121-1129

UT code for WoS article

000598704600001

EID of the result in the Scopus database

2-s2.0-85102484789