Immunological configuration of ovarian carcinoma: features and impact on disease outcome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10432800" target="_blank" >RIV/00216208:11110/21:10432800 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10432800 RIV/00064165:_____/21:10432800 RIV/00216208:11130/21:10432800
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nvRAN59b3H" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nvRAN59b3H</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/jitc-2021-002873" target="_blank" >10.1136/jitc-2021-002873</a>

Result language
angličtina
Original language name
Immunological configuration of ovarian carcinoma: features and impact on disease outcome
Original language description
Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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