Assessment of the Effects of Drugs on Mitochondrial Respiration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10440646" target="_blank" >RIV/00216208:11110/21:10440646 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/978-1-0716-1270-5_9" target="_blank" >https://doi.org/10.1007/978-1-0716-1270-5_9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-0716-1270-5_9" target="_blank" >10.1007/978-1-0716-1270-5_9</a>
Alternative languages
Result language
angličtina
Original language name
Assessment of the Effects of Drugs on Mitochondrial Respiration
Original language description
Mitochondria are targets of newly synthesized drugs and being tested for the treatment of various diseases caused or accompanied by disruption of cellular bioenergetics. In drug development, it is necessary to test for drug-induced changes in mitochondrial enzyme activity that may be related to therapeutic or adverse drug effects. Measurement of drug effect on mitochondrial oxygen consumption kinetics and/or protective effects of drugs against calcium-induced inhibition of the mitochondrial respiration can be used for the study mitochondrial toxicity and neuroprotective effects of drugs. Supposing that the drug-induced inhibition of the mitochondrial respiratory rate and/or individual mitochondrial complexes is associated with adverse drug effects, the effects of drugs on mitochondrial respiration in isolated mitochondria allow selection of novel molecules that are relatively safe for mitochondrial toxicity.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Mitochondrial Medicine. Volume 3: Manipulating Mitochondria and Disease- Specific Approaches
ISBN
978-1-07-161269-9
Number of pages of the result
10
Pages from-to
133-142
Number of pages of the book
468
Publisher name
Humana Press
Place of publication
New York
UT code for WoS chapter
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