Free vitamin D is independently associated with systolic blood pressure in diabetic patients with impaired kidney function
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F22%3A10437882" target="_blank" >RIV/00216208:11110/22:10437882 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hkhg6Fbcjd" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hkhg6Fbcjd</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5414/CN110549" target="_blank" >10.5414/CN110549</a>
Alternative languages
Result language
angličtina
Original language name
Free vitamin D is independently associated with systolic blood pressure in diabetic patients with impaired kidney function
Original language description
Vitamin D contributes to blood pressure (BP) regulation. We compared the association of BP in diabetic patients with either total vitamin D - the standard way of analyzing the vitamin D status - or free vitamin D, because only free vitamin D passes the cell membrane and interacts with the nuclear vitamin D receptor (VDR). An analytical cross-sectional study was conducted with 178 diabetic patients with impaired kidney function. Free and total vitamin D concentrations were measured in all patients. Multiple linear regression analysis considering patient age, sex, body mass index, height, smoking and drinking situation, the use of antihypertensive drugs, cholecalciferol treatment, C reactive protein and estimated glomerular filtration rate as confounding factors were conducted to compare the association of free and total vitamin D with systolic and diastolic blood pressure (SBP and DBP). Multiple linear regression analysis revealed that neither SBP nor DBP was correlated with total vitamin D (SBP, 95% CI -0.405 similar to 0.159, p = 0.390; DBP, 95% CI -0.131 similar to 0.142, p = 0.933) (Table 2). the concentration of free vitamin D was independently associated with SBP (95% CI -2.691 similar to -0.210; p = 0.022) (Table 3), but not with DBP (95% CI -0.934 similar to 0.285; p = 0.293). In conclusion, free - but not total - vitamin D serum concentrations in patients with diabetes and impaired kidney function are inversely correlated with SBP. This study suggests that free vitamin D measurements might be more clinically relevant - as compared to measurements of total vitamin D - to adjust vitamin D therapy in diabetic patients with impaired kidney function.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Nephrology
ISSN
0301-0430
e-ISSN
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Volume of the periodical
97
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
63-69
UT code for WoS article
000744000200001
EID of the result in the Scopus database
2-s2.0-85123877884