SPECT imaging properties of the CdTe-Timepix3 detector used in a new prototype FullSPECT 3D multimodal preclinical imaging system: Comparison with scintillation gamma camera
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F22%3A10442495" target="_blank" >RIV/00216208:11110/22:10442495 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TLFL20s8Jb" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TLFL20s8Jb</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nima.2022.166531" target="_blank" >10.1016/j.nima.2022.166531</a>
Alternative languages
Result language
angličtina
Original language name
SPECT imaging properties of the CdTe-Timepix3 detector used in a new prototype FullSPECT 3D multimodal preclinical imaging system: Comparison with scintillation gamma camera
Original language description
Small animal SPECT imaging represents a fast-evolving method for a noninvasive molecular imaging of metabolism, diseases, or malfunctions in live animal models. Preclinical imaging is important for translational research related to development and testing of new tracers, diagnostic and therapeutic methods for clinical application, and helps also in basic biological research. The small animal imaging requires better spatial resolution compared to human imaging. The improvement on the detector side should be implemented because the currently used scintillation gamma cameras are now touching their limits. The main goal of this work aims on introduction of a new concept of our prototype system (FullSPECT 3D) and comparison of the performance of its hybrid semiconductor Timepix3 based detector, and standard scintillation gamma camera in a commercially available device (Albira Preclinical Imaging System) for SPECT imaging on phantom and animal model. We compared both detector types on widely used Tc-HDP (for bone scan), and 125I labeled antibody biodistribution assays. The images taken with a single Timepix3 based detector were comparable and in some parameters exceeded standard detectors under similar geometry in 2D projections. The differences in 3D reconstructed images were not calculated because of the huge difference in the reconstruction algorithms, nevertheless the 3D images are shown as well. The future SPECT systems could benefit from the speed, energy resolution and size of Timepix3 based detectors and open the way to construction of very fast multimodal imagers requiring less ionizing radiation delivered to the patient.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment
ISSN
0168-9002
e-ISSN
1872-9576
Volume of the periodical
1032
Issue of the periodical within the volume
June
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
166531
UT code for WoS article
000793768200004
EID of the result in the Scopus database
2-s2.0-85127309054