Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F23%3A10459038" target="_blank" >RIV/00216208:11110/23:10459038 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XUEQOOW6qu" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XUEQOOW6qu</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.202200516" target="_blank" >10.1002/mabi.202200516</a>
Alternative languages
Result language
angličtina
Original language name
Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery
Original language description
Osteoarthritisis a highly prevalent musculoskeletal disorder characterized by degradation ofcartilage and synovial fluid (SF). Platelet derivatives as platelet-rich plasma (PRP) and platelet lysatehave great potential in the treatment of osteoarthritis because they contain biologicallyactive substances including growth factors (GFs). Rapid release of GFs andtheir short biological half-life are factors that can limit the therapeuticimpact of PRP therapy. Here, the first work that describes hydrogels based onpolyaldehyde derivative of hyaluronic acid (HA-OX) as carriers of plateletderivatives for in situ applications is presented, which can be a possiblesolution to the problem. HA-OX hydrogels containing 50% (w/w) of PRP or platelet lysate can be injected using a syringe due to low viscosity(<10 Pa s) and injection force (<20 N), and reach elastic modulus upto 2000 Pa. Insulin-like GF-1 and Platelet-derived GF-AB release from HA-OX hydrogels (mesh size 297-406 nm) by Fickian and non-Fickian diffusion respectively. The released PRP GFs maintain their ability to induce cell proliferation (87%-92%). Based on the obtained results, the unique concept of a new material that canrestore viscoelastic properties of SF and at the same time gradually deliver GFs from platelet derivatives is designed.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30100 - Basic medicine
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
1616-5195
Volume of the periodical
23
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
2200516
UT code for WoS article
000930163600001
EID of the result in the Scopus database
2-s2.0-85147939224