Metabolomics and proteomics in pheochromocytoma and paraganglioma: Translating biochemistry and biology to bedside

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10489226" target="_blank" >RIV/00216208:11110/24:10489226 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xVvJsCJq9s" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=xVvJsCJq9s</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.beem.2024.101935" target="_blank" >10.1016/j.beem.2024.101935</a>

Result language

angličtina

Original language name

Metabolomics and proteomics in pheochromocytoma and paraganglioma: Translating biochemistry and biology to bedside

Original language description

The complexity of omes - the key cellular ensembles (genome and epigenome, transcriptome, proteome, and metabolome) - is becoming increasingly understood in terms of big-data analysis, the omics. Amongst these, proteomics provides a global description of quantitative and qualitative alterations of protein expression (or protein abundance in body fluids) in response to physiologic or pathologic processes while metabolomics offers a functional portrait of the physiological state by quantifying metabolite abundances in biological samples. Here, we summarize how different techniques of proteomic and metabolic analysis can be used to define key biochemical characteristics of pheochromocytomas/paragangliomas (PPGL). The significance of omics in understanding features of PPGL biology that might translate to improved diagnosis and treatment will be highlighted.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism

ISSN

1521-690X

e-ISSN

1532-1908

Volume of the periodical

38

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

101935

UT code for WoS article

001375708200001

EID of the result in the Scopus database

2-s2.0-85204351987