Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10497236" target="_blank" >RIV/00216208:11110/25:10497236 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1eD.hcFxU2" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1eD.hcFxU2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.nbd.2025.106830" target="_blank" >10.1016/j.nbd.2025.106830</a>
Alternative languages
Result language
angličtina
Original language name
Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease
Original language description
Background: This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. Methods: After presurgical speech analysis, we recorded STN neuronal activities while PD patients (n = 16) articulated Chinese Pinyin consonants. The Pinyin consonants were categorized by the manner and place of articulation for SUA cluster analysis. The cohort was then divided into normal articulation and dysarthria groups based on diadochokinetic (DDK) assessments. The STN SUA patterns, represented by the mean firing rate (FR), peak time, and response intensity during articulation, were analyzed and compared between the two groups. Finally, a stimulation cohort of 7 PD patients was included to test articulation and SUA pattern changes following intraoperative DBS. Results: Clustering analysis of STN neuronal firing patterns demonstrated that neurons encode articulation by grouping consonants with the same manner of articulation into distinct clusters. Using k-means clustering, we further classified SUAs into two waveform types: negative spikes (type 1) and positive spikes (type 2). Dysarthria patients exhibited an increased mean FR of type 1 spikes and a reduced response intensity of type 2 spikes. During intraoperative stimulation, PD patients showed accelerated DDK, accompanied by a decrease in type 1 mean FR and an increase in type 2 mean FR. Conclusion: Our findings indicate the crucial role of the STN in consonant encoding and dysarthria at the single- unit level. Both SUA firing patterns in the STN and DDK performance can be modulated by DBS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurobiology of Disease
ISSN
0969-9961
e-ISSN
1095-953X
Volume of the periodical
207
Issue of the periodical within the volume
April
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
106830
UT code for WoS article
001428967800001
EID of the result in the Scopus database
2-s2.0-85217967059