Ferroptosis Mediates Zinc Toxicity: Implications for Cancer Therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10498072" target="_blank" >RIV/00216208:11110/25:10498072 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nzs0MkZJCA" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nzs0MkZJCA</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.32604/biocell.2025.063301" target="_blank" >10.32604/biocell.2025.063301</a>
Alternative languages
Result language
angličtina
Original language name
Ferroptosis Mediates Zinc Toxicity: Implications for Cancer Therapy
Original language description
Ferroptosis is an iron-driven, phospholipid hydroperoxide-mediated cell death, which has recently emerged as an attractive tool in cancer research due to its ability to govern the anti-tumor immune response. A growing research interest in ferroptosis biology has revealed the contribution of this regulated cell death to multiple diseases. In addition to iron, ferroptosis has been reported to be triggered by multiple heavy metals, which sheds light on the novel aspects of heavy metals-induced cytotoxicity. In this review, the ability of zinc, an essential biogenic element with a wide array of biological functions, to modulate ferroptosis in normal and malignant cells has been summarized. Accumulating evidence suggests that zinc-induced biological effects can be mediated by ferroptosis induction or attenuation. In addition, the anti-cancer effects of zinc can be at least partly attributed to ferroptosis induction. The signaling pathways governing zinc-regulated ferroptosis are highlighted. It has been underscored that zinc-mediated modulation of ferroptosis is dependent on alterations of redox homeostasis, antioxidant defense (in particular, the SLC7A11/GSH/GPX4 axis), and iron metabolism. Additionally, data on ferroptosis induction by zinc oxide nanoparticles are summarized to emphasize the potential of these nanomaterials as a promising therapeutic choice in anti-cancer treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10600 - Biological sciences
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biocell
ISSN
0327-9545
e-ISSN
1667-5746
Volume of the periodical
49
Issue of the periodical within the volume
5
Country of publishing house
AR - ARGENTINA
Number of pages
21
Pages from-to
721-741
UT code for WoS article
001454316100001
EID of the result in the Scopus database
2-s2.0-105006686682