Longitudinal analysis of pupillometry according to type of pharmacotherapy in Parkinson's disease patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10501917" target="_blank" >RIV/00216208:11110/25:10501917 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/25:10501917

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Ifr_upcxrJ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Ifr_upcxrJ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-15306-z" target="_blank" >10.1038/s41598-025-15306-z</a>

Result language

angličtina

Original language name

Longitudinal analysis of pupillometry according to type of pharmacotherapy in Parkinson's disease patients

Original language description

The aim of this study was to evaluate the effect of different types of pharmacotherapy on pupillometric parameters in PD patients. Dopamine was shown to induce mydriasis by excitation of alpha-adrenergic receptors at the dilator pupillae muscle. Pupil diameter may thus serve as an indirect measure of peripheral dopaminergic activity. A total of 63 PD patients were treated with different types of dopaminergic pharmacotherapy. Pupil examination was performed before the first application of dopaminergic pharmacotherapy and then after one year of treatment in the OFF state and in the ON state. There were significant differences in pupillometric parameters obtained at baseline and at year 1 OFF and ON. The pupillometry did not differ among type of used pharmacotherapy in most pupillometric parameters. Two-way ANOVA confirmed the significant effect of visit in the pupillometric parameters MAX and MIN, but did not confirm the significant effect treatment between groups of patients with L-DOPA pharmacotherapy and with dopamine agonist. Linear regression analysis showed significant dose-response relationships between the most pupillometric parameters and L-DOPA equivalent doses in the patients treated with L-DOPA and dopamine agonist. In conclusion, this analysis does not confirm a differential pupillary response according to type of pharmacotherapy in PD patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

30525

UT code for WoS article

001577164900036

EID of the result in the Scopus database

2-s2.0-105013870594