Pupillometry as an indicator of L-DOPA dosages in Parkinson's disease patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10374158" target="_blank" >RIV/00216208:11110/18:10374158 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/18:10374158

Result on the web

<a href="http://dx.doi.org/10.1007/s00702-017-1829-1" target="_blank" >http://dx.doi.org/10.1007/s00702-017-1829-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-017-1829-1" target="_blank" >10.1007/s00702-017-1829-1</a>

Result language

angličtina

Original language name

Pupillometry as an indicator of L-DOPA dosages in Parkinson's disease patients

Original language description

Dopamine was shown to induce mydriasis by excitation of alpha-adrenergic receptors at the dilator pupillae muscle. Pupilla diameter may thus serve as an indirect measure of peripheral pharmacokinetics of l-DOPA and dopamine. The aim of this study is to evaluate the effect of l-DOPA dosage on pupillometric parameters in Parkinson&apos;s disease (PD) patients. Sixteen PD patients and 14 healthy control subjects (CS) were studied. The statistical analysis revealed significant differences between CS and PD patients for the mean maximum and minimum pupil diameters (p = 0.017, p = 0.028, respectively), with higher values found in PD. Moreover, a significant dose-response relationship was found between the maximum pupil diameter and both the morning l-DOPA dose (R (2) = 0.78) and the total daily l-DOPA dose (R (2) = 0.93). A sigmoid-shaped curve best describes the dose-response relationship, with a ceiling effect at about 400 mg l-DOPA daily dose. In conclusion, measuring pupillometric parameters represents a sensitive tool for non-invasive evaluation of the peripheral effect of l-DOPA, especially with daily doses below 400 mg l-DOPA.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

—

Volume of the periodical

125

Issue of the periodical within the volume

4

Country of publishing house

AT - AUSTRIA

Number of pages

5

Pages from-to

699-703

UT code for WoS article

000427658500007

EID of the result in the Scopus database

2-s2.0-85038368842