Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9530" target="_blank" >RIV/00216208:11110/11:9530 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/11:9530
Result on the web
<a href="http://dx.doi.org/10.1111/j.1365-2710.2010.01203.x" target="_blank" >http://dx.doi.org/10.1111/j.1365-2710.2010.01203.x</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pupillometry in healthy volunteers as a biomarker of tramadol efficacy
Original language description
What is known and Objective: The opioid effect of tramadol, which can be detected by pupillary response, is predominantly mediated by the O-demethylated metabolite, formed via CYP2D6. This study was designed to evaluate the effects of tramadol using different parameters of pupillometry as biomarkers. Methods: Sixty-nine healthy volunteers received tramadol hydrochloride drops orally at a dose of 0.7 mg/kg. Pre-dose and 2-h post-dose pupillometric measurements were performed. The polymorphism of CYP2D6 was analysed. Results and Discussion: Large interindividual variability was observed in the tramadol-induced pupillary reaction. Miosis was induced in 69.6% and mydriasis in 30.4% of the subjects. The pupillary response differed in relation to the CYP2D6genotype. A maximal difference in initial pupil diameter of 0.81 mm was found in extensive metabolizers. There were significant effects observed on the pupillary light reflex parameters with tramadol administration (P < 0.05) except for t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Pharmacy and Therapeutics
ISSN
0269-4727
e-ISSN
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Volume of the periodical
36
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
513-517
UT code for WoS article
000292464300008
EID of the result in the Scopus database
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