Ruthenium-enhanced curcumin derivatives target tumor growth and cancer-related inflammation in head and neck cancer models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10507842" target="_blank" >RIV/00216208:11110/25:10507842 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143759 RIV/00064165:_____/25:10507842
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TduAgxtODB" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=TduAgxtODB</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fonc.2025.1708944" target="_blank" >10.3389/fonc.2025.1708944</a>

Result language
angličtina
Original language name
Ruthenium-enhanced curcumin derivatives target tumor growth and cancer-related inflammation in head and neck cancer models
Original language description
Introduction Head and neck cancers (HNC) remain a significant clinical challenge, particularly due to their association with chronic inflammation triggered by tobacco carcinogens and human papillomavirus (HPV) infection. Persistent activation of proinflammatory and proangiogenic pathways, including nuclear factor kappa B (NF-kB), interleukin 6 (IL-6), and interleukin 8 (IL-8), plays a crucial role in tumor progression.Methods In this study, we synthetized ruthenium-enhanced curcumin derivatives (complexes 3 and 4) and study their anti-inflammatory and anticancer properties by using HNC cell lines.Results Complex 3 demonstrated potent cytotoxic and antiproliferative effects across both HPV-negative and HPV- positive HNC cell lines, while complex 4 showed selectivity toward oral squamous cell carcinoma (OSCC). Both complexes exhibited cytostatic and migrastatic activities. Importantly, treatment with these complexes significantly suppressed NF-kB activity and reduced IL-6 and IL-8 levels more effectively than native curcumin.Discussion These findings highlight their potential not only as stand-alone therapeutic agents but also as adjuvants in combination therapies for HNC.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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