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Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F00%3A00003729" target="_blank" >RIV/00216208:11120/00:00003729 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1078/0065-1281-00573" target="_blank" >http://dx.doi.org/10.1078/0065-1281-00573</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1078/0065-1281-00573" target="_blank" >10.1078/0065-1281-00573</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression of beta-catenins and cadherins by follicular dendritic cells in human lymph nodes

  • Original language description

    n lymph nodes, dendritic cells form a complex meshwork and are linked by intercellular junctions. Intercellular junctions contribute to the integrity of lymphatic follicles and can potentially be affected by malignant processes in neighbouring B cells. We examined whether transmembrane molecules that constitute "adherens junctions" are present in follicular dendritic cells of normal human lymph nodes. We found that follicular dendritic cells but not interdigitating dendritic cells or sinus lining cellsexpressed cadherin molecules. Follicular dendritic cells also expressed beta -catenin but not vinculin. The cadherin molecules, which were identified in situ with the use of a monoclonal pan-cadherin antibody, were not recognized by antibodies to E-cadherin, N-cadherin or beta -cadherin. Intrafollicularly, cadherins were clearly colocalized with beta -catenins, in a dot-like fashion. We also detected intrafollicular expression of desmogleins and desmosomal plaque proteins. These findings

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/VS96129" target="_blank" >VS96129: Laboratory of gene expression</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2000

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Histochemica

  • ISSN

    0065-1281

  • e-ISSN

  • Volume of the periodical

    102

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    16

  • Pages from-to

    369-380

  • UT code for WoS article

    000165865000001

  • EID of the result in the Scopus database