Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A00003660" target="_blank" >RIV/00216208:11120/01:00003660 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Prevalence of hereditary non-polyposis colorectal cancer (HNPCC) in Czech patients with endoscopic diagnosis of colorectal cancer
Original language description
Background and Study Aims: The hereditary non-polyposis colorectal cancer (HNPCC) syndrome is caused by germline mutations in MMR genes and predisposed individuals to cancers of the colon and other specific sites. We assessed the prevalence of HNPCC in Czech patient with endoscopic diagnosis of colorectal cancer. Patient and Methods: We examined 2,464 patients by total colonoscopy. Patient with CRC suspected of HNPCC we screened for germline mutations of mismatch repair genes hMLH1 and hMLH2. Results: Out of a total of 2,464 patients examined 128 were found to have CRC. We found germline mutation in hMLH1 gene in two patients (1.5%). Conclusions: The occurrence of hereditary cancer in Czech patients is lower than suspected, probably in accordance witha high share of sporadic colorectal cancer.
Czech name
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Czech description
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Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
8th Biennial Congress of the European Council of Coloproctology (ECCP)
ISBN
88-323-1429-0
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
219-224
Publisher name
Medimond
Place of publication
Bologna
Event location
Praha
Event date
Jan 1, 2001
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000172544200034

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