Experimental pharmacotherapy of opioid sensitization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A43902434" target="_blank" >RIV/00216208:11120/01:43902434 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Experimental pharmacotherapy of opioid sensitization

Original language description

This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Sensitisation hasbeen recently one of the main subjects of interest in the research of drug addiction. Contrary to tolerance, sensitisation is characterised by increased behavioural reaction after repeated administration of a drug. Sensitisation seems to be one of the causes of dependence generation on the opioids and relapse in ex-addict people. This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Most studies focus on the dopaminergic, glutamatergic, gabaergic and serotoninergic receptor systems. However, none of the tested substances has proved to be ideal for sensitis

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Homeostasis in Health and Disease

ISSN

0960-7560

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

3-4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

123-131

UT code for WoS article

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EID of the result in the Scopus database

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