Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F03%3A00007362" target="_blank" >RIV/00216208:11120/03:00007362 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Antimutagenic Effect of Resveratrol and Diallylsulphide and its Effect on the Immune Response in Mice
Original language description
Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of Resveratrol (RES) and Diallylsulphide (DAS) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxinB1 (AFB1), and N-nitroso-N-methylurea (MNU). The protective effect of resveratrol and diallyl sulfide was assessed by the chemiluminescence method detecting the production of oxygen radicals, namely the production of the complex of hydrogen peroxide-myeloperoxidase-halid cofactor during phagocytosis, and by the blastic transformation method testing the functional capacity of T-lymphocytes. In all of the experiments resveratrol and diallyl sulfide to a significant degree repaired the immunosuppressive effects of all three carcinogens tested. Resveratrol and diallyl sulfide demonstrably inhibits the mutagenic activity of three reference mutagens.
Czech name
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Czech description
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Project
<a href="/en/project/NJ7462" target="_blank" >NJ7462: Antimutagenic and immunomodulative effects of selected natural substances.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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