The functional association between COMT gene polymorphism and visual attention in schizophrenic psychosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F03%3A00007451" target="_blank" >RIV/00216208:11120/03:00007451 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/03:00000275 RIV/00216208:11150/03:00004423
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The functional association between COMT gene polymorphism and visual attention in schizophrenic psychosis
Original language description
Catechol-O-methyl transferase (COMT) is the postsynaptic enzyme that inactivates released dopamine and other catacholamins. The COMT activity is polymorphic due to the G to A transition at codon 158 on chromosome 22q11 which translates into valine-to-methionine change in the peptide sequence. COMT with Val allele more rapidly inactivate released dopamine comparing to Met allele. In our study we found in the group of 44 patients with schizophrenic disorder that COMT polymorphism influences the outcome invisual attention measured by the CPT II test. ValVal homozygotes have worst outcome in commission errors and reaction time (p 0,05). These finding confirms the role of COMT polymorphism and in cognitive deficit in schizophrenia.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Project
<a href="/en/project/LN00B122" target="_blank" >LN00B122: Neuropsychiatric Research Center</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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