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Dexmedetomidine selectively suppresses dominant behaviour in aggressive and sociable mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F05%3A00009569" target="_blank" >RIV/00216208:11120/05:00009569 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023001:_____/05:00001283

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dexmedetomidine selectively suppresses dominant behaviour in aggressive and sociable mice

  • Original language description

    The present results suggest that dexmedetomidine appears to inhibit predominantly dominant behaviour evoked by biologically important stimuli. In a novel environment dexmedetomidine inhibited locomotion, in sociable mice sociable activities and in aggressive mice aggression. Selective antiaggressive effect was not described very often and dexmedetomidine is already used in human medicine and thus can be used for treatment of aggressive states.

  • Czech name

    Dexmedetomidin selektivně inhibuje dominantní chování u agresivních a sociabilních myší

  • Czech description

    Výsledky ukazují, že dexmedetomidin inhibuje především chování, které je stimulováno biologicky dominantními stimuly. V novém prostředí dexmedetomidin inhibuje lokomoci, u sociabilních myší sociabilitu a u agresivních myší agresivitu. Selektivní antiagresivní účinek je popisován zřídka a protože je dexmedetomidin používán v humánní medicíně, může být používán pro léčbu agresivních stavů.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GP305%2F05%2FP003" target="_blank" >GP305/05/P003: Research of anxiolytic activity of alpha2 adrenergic agonists</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Pharmacology

  • ISSN

    0014-2999

  • e-ISSN

  • Volume of the periodical

    523

  • Issue of the periodical within the volume

    1-3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    7

  • Pages from-to

    79-85

  • UT code for WoS article

  • EID of the result in the Scopus database