Regulation of Ca2+ Signaling in Mast Cells by Tyrosine-Phosphorylated and Unphosphorylated Non-T Cell Activation Linker

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000234" target="_blank" >RIV/00216208:11120/07:00000234 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/07:00089650

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Regulation of Ca2+ Signaling in Mast Cells by Tyrosine-Phosphorylated and Unphosphorylated Non-T Cell Activation Linker

Original language description

Engagement of the FcERI in mast cells and basophils leads to a rapid tyrosine phosphorylation of the transmembrane adaptors LAT (linker for activation of T cells) and NTAL (non-T cell activation linker, also called LAB or LAT2). NTAL regulates activationof mast cells by a mechanism, which is incompletely understood. Here we report properties of rat basophilic leukemia cells with enhanced or reduced NTAL expression. Overexpression of NTAL led to changes in cell morphology, enhanced formation of actin filaments and inhibition of the FcERI-induced tyrosine phosphorylation of the FcERI subunits, Syk kinase and LAT and all downstream activation events, including calcium and secretory responses. In contrast, reduced expression of NTAL had little effect on early FcERI-induced signaling events but inhibited calcium mobilization and secretory response. Calcium response was also repressed in Ag-activated cells defective in Grb2, a major target of phosphorylated NTAL. Unexpectedly, in cells stim

Czech name

Regulace vápníkové signalizace v žírných buňkách prostřednictvím tyrosin-fosforylovaného a nefosforylovaného adaptoru NTAL

Czech description

V časných fázích signalizace přes vysokoafinitní IgE receptor NTAL intrferuje s tyrosinovou fosforylací řady substrátů a s formováním signálních komplexů, zatímco v pozdních stádiích aktivace reguluje aktivitu SOC vápníkových kanálů mechanismem nezávislým na své fosforylaci

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Immunology

ISSN

0022-1767

e-ISSN

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Volume of the periodical

179

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

5169-5180

UT code for WoS article

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EID of the result in the Scopus database

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