Plasma Levels and Adipose Tissue Messenger Ribonucleic Acid Expression of Retinol-Binding Protein 4 Are Reduced during Calorie Restriction in ObeseSubjects but Are Not Related to Diet-Induced Changes in Insulin Sensitivity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000290" target="_blank" >RIV/00216208:11120/07:00000290 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Plasma Levels and Adipose Tissue Messenger Ribonucleic Acid Expression of Retinol-Binding Protein 4 Are Reduced during Calorie Restriction in ObeseSubjects but Are Not Related to Diet-Induced Changes in Insulin Sensitivity
Original language description
Context: Retinol-binding protein 4 (RBP4) may play a role in the development of insulin resistance. Objective: We investigated whether RBP4 adipose tissue mRNA expression and plasma level are related to insulin sensitivity during a diet-induced weight loss. Design, Setting, Patients, and Intervention: Obese women followed a dietary intervention composed of a 4-wk very low-calorie diet (VLCD), a 2-month low-calorie diet, and 3?4 months of a weight maintenance (WM) phase. Main Outcome Measures: Clinical investigation was performed before and at the end of each phase. Insulin sensitivity was assessed with the euglycemic hyperinsulinemic clamp. Adipose tissue mRNA and plasma levels of RBP4 were determined using reverse transcription-quantitative PCR and ELISA, respectively. Results: Weight and fat mass decreased during VLCD and were stabilized during WM. Glucose disposal rate increased during VLCD and remained elevated thereafter. Plasma levels of RBP4 decreased afterVLCDand, although incr
Czech name
Plasmatické hladiny a mRNA retinol-vázajícího proteinu-4 v tukové tkáni se snižují během kalorické restrikce u obézních, ale nesouvisí se změnami v insulinové resistenci
Czech description
Autoři popisují, že se plasmatické hladiny a mRNA retinol-vázajícího proteinu-4 v tukové tkáni snižují během kalorické restrikce u obézních, ale nesouvisí se změnami v insulinové resistenci
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA303%2F04%2F0158" target="_blank" >GA303/04/0158: Role of adipose tissue in ethiopatogenesis of insulin resistence in woman with polycystic ovary syndrome</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
2330-2335
UT code for WoS article
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EID of the result in the Scopus database
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