Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43903599" target="_blank" >RIV/00216208:11120/12:43903599 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2011-2380" target="_blank" >http://dx.doi.org/10.1210/jc.2011-2380</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2011-2380" target="_blank" >10.1210/jc.2011-2380</a>

Result language
angličtina
Original language name
Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women
Original language description
Obesity is associated with altered plasma levels of adipokines involved in the development of insulin resistance and obesity-related metabolic disturbances.Objective:The aim was to investigate diet-induced changes in adipokine production in sc abdominaladipose tissue (SAT) during a 6-month, multiphase, weight-reducing dietary intervention.Design, Setting, Participants, and Interventions:Forty-eight obese women followed a dietary intervention consisting of a very low-calorie diet (VLCD) (1 month), followed by a weight-stabilization (WS) period, which consisted of a low-calorie diet (2 months), and a weight-maintenance diet (3 months).Main Outcome Measures:Before and at the end of the VLCD and WS, samples of plasma and SAT were obtained. In a subgroup of 26 women, secretion of adipokines was determined in SAT explants, and in a subgroup of 22 women, SAT mRNA expression was measured.Results:Body weight decreased and insulin sensitivity increased during the intervention. Plasma levels, SA
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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