Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002392" target="_blank" >RIV/00216208:11120/11:00002392 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/ijo.2010.112" target="_blank" >http://dx.doi.org/10.1038/ijo.2010.112</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ijo.2010.112" target="_blank" >10.1038/ijo.2010.112</a>

Result language
angličtina
Original language name
Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women
Original language description
Accumulation of adipose tissue macrophages (ATMs) is observed in obesity and may participate in the development of insulin resistance and obesity-related complications. The aim of our study was to investigate the effect of long-term dietary interventionon ATM content in human adipose tissue.Design:We performed a multi-phase longitudinal study. A total of 27 obese pre-menopausal women (age 39+/-2 years, body mass index 33.7+/-0.5 kg m(-2)) underwent a 6-month dietary intervention consisting of two periods: 4 weeks of very low-calorie diet (VLCD) followed by weight stabilization composed of 2 months of low-calorie diet and 3to 4 months of weight maintenance diet. At baseline and at the end of each dietary period, samples of subcutaneous adipose tissue (SAT) were obtained by needle biopsy and blood samples were drawn. ATMs were determined by flow cytometry using combinations of cell surface markers. Selected cytokine and chemokine plasma levels were measured using enzyme-linked immunosor
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NS10519" target="_blank" >NS10519: Relative abundance of macrophages and other cell populations in adipose tissue in relation to obesity and associated metabolic complications</a><br>
Continuities
O - Projekt operacniho programu

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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