An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced pre-menopausal women

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000291" target="_blank" >RIV/00216208:11120/07:00000291 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced pre-menopausal women

Original language description

Adiponectin is involved in the regulation of glucose and fatty acid metabolism, influences wholebody insulin sensitivity and protects arterial walls against the development of atherosclerosis. Plasma adiponectin is decreased in obese, insulin-resistant and Type 2 diabetic patients. Adiponectin circulates in plasma as high-, medium- and low-molecular mass forms (HMW, MMW and LMW respectively). The HMW form is believed to be closely associated with insulin sensitivity. The aim of the present study was toinvestigate whether diet-induced changes in body weight and insulin sensitivity were associated with changes in the quantity of adiponectin multimeric complexes. A total of 20 overweight or obese women (age, 39.4+-9.5 years; body mass index, 32.2+- 6.4 kg/m2) underwent 12 weeks of low caloric diet (600 kcal/day less than energy requirements; where 1 kcal&#8776;4.184 kJ). Plasma samples were drawn before and after the study for biochemical analysis andWestern blot detection of adiponectin

Czech name

Vzestup polymerních izoforem adiponektinu po váhovém úbytku navozeném hypokalorickou dietou u premenopauzálních žen

Czech description

Cílem studie bylo porovnat, zda jsou dietou indukované změny v inzulínové senzitivtě asociovány se změnami ve kvantitě polymerních izoforem adiponektinu. Celkem se 20 žen (věk 39.4+-;9.5 let; BMI, 32.2+- 6.4 kg/m2) podrobilo 12 týdenní nízkokalorické dietě. Adiponektin byl detekován pomocí western blotu. Pozorovali jsme zvýšení kvantity HMW? MMW i LMW formy adiponectinu o 5.5, 8.5 and 18.1% (p<0.05). celkový adiponektin se po intervenci snížil o 36% (P=0.08)

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Science

ISSN

0143-5221

e-ISSN

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Volume of the periodical

112

Issue of the periodical within the volume

11-12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

557-565

UT code for WoS article

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EID of the result in the Scopus database

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