Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F04%3A00001143" target="_blank" >RIV/00216208:11120/04:00001143 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance
Original language description
Adiponectin, a newly discovered adipose-tissue-specific protein, is thought to be involved in the regulation of insulin action. The aim of the present study was to determine whether adiponectin contributes to the improvement in insulin sensitivity duringvery-low-calorie diet (VLCD). Biopsies of sc abdominal adipose tissue and blood sampling for analysis of plasma adiponectin and related hormones and metabolites were performed before and at the end of a 4-wk VLCD in 33 nonmorbidly obese women (body massindex, 34.4 +/- 4.1 kg/m(2)). VLCD produced a decrease in weight (7.1 +/- 0.4 kg) and in insulin and leptin levels and led to an improvement in insulin sensitivity. Adiponectin gene expression and plasma levels were not modified during calorie restriction. Before VLCD, we found negative correlations between plasma adiponectin and variables related to the metabolic syndrome. Adiponectin mRNA levels showed a negative correlation with lipoprotein a plasma values.
Czech name
Genové exprese a plazmatické hladiny adiponektinu u obézních žen při valmi nízko kalorické dietě. Vztah kekardiovaskulárnímu riziku a inzulínové rezistenci
Czech description
Byly sledovány korelace mezi adiponektinem (plazmatickou hladinou a genovou expresí vbiopsii ztukové tkáně) a dalšími proměnnými vztahujícími se kmetabolickému syndromu (lipoproteiny, inzulínová senzitivita). Adiponektin (v plazmě i genové exprese) se podietě nezměnil. Byly prokázané korelace adiponektinu sněkterými proměnnými spojenými smetabolickým syndromem před zahájením diety, tyto korelace se však neprokázaly po intervenci. Výsledky naznačují, že adiponektin má vztah kochraně před metabolickým syndromem, ale není zahrnut do regulace zlepšení inzulínové senzitivity po VLCD.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X
e-ISSN
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Volume of the periodical
89
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
756-760
UT code for WoS article
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EID of the result in the Scopus database
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