Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000295" target="_blank" >RIV/00216208:11120/07:00000295 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists
Original language description
he role of PPARs in the regulation of human adipose tissue secretome has received little attention despite its potential importance in the therapeutic actions of PPAR agonists. Here, we have investigated the effect of selective PPARgamma, PPARalpha, andPPARbeta/delta agonists on the production of adipokines by human subcutaneous adipose tissue. Antibody arrays were used to measure secreted factors in media from cultured adipose tissue explants. Sixteen proteins were produced in significant amounts. Activation of PPARs regulated the production of five proteins. Treatments with the three PPAR agonists decreased the secretion of leptin and interleukin-6. PPARalpha and beta/delta agonists markedly enhanced hepatocyte growth factor secretion whereas PPARbeta/delta down-regulated angiogenin and up-regulated TIMP-1 release. Hepatocyte growth factor, interleukin-6, and TIMP-1 are chiefly expressed in cells from the stromal vascular fraction whereas angiogenin is expressed in both adipocytes a
Czech name
Efekt PPAR agonistov na sekreciu adipokinov z ludskeho podkozneho tukoveho tkaniva
Czech description
Sledovali sme efekt PPAR gamma, PPAR alpha a PPAR beta/delta agonistov na produkciu adipokinov ludskym podkoznym tukovym tkanivom. Kazdy z PPAR ligandov znizil sekreciu leptinu a interleukinu 6. PPAR alpha a PPAR beta/delta agonisti zvysili sekreciu HGF,zatial co PPAR beta/delta znizil produkciu angiogeninu a zvysil produkciu TIMP-1
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR8066" target="_blank" >NR8066: The role of visceral adipose tissue in ethiopathogenesy of metabolic syndrome investigated on a level of molecular genetic characteristics of tissue</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochemical and Biophysical Research Communications
ISSN
0006-291X
e-ISSN
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Volume of the periodical
358
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
897-902
UT code for WoS article
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EID of the result in the Scopus database
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