Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000303" target="_blank" >RIV/00216208:11120/07:00000303 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Expression and production of spinal cyclooxygenase 1 and 2 in the model of experimental osteoarthritis
Original language description
Osteoarthritis (OA) is a degenerative joint disease.Th ejoints are characterized by a progressive degeneration of articular cartilage leading to inflammattion and pain.In attempt to study the pathophysiology of OA, numerous experimental model that mimichuman OA have been developed.Chemical models of OA involve intraarticular injection of chemical compounds that can have a number of effects on joint physiology.Surgical models of OA induce joint instability by partial menisectomy.One of the most frequently used model is the model of monoiodoacetate (MIA) induced OA.Local injection of monoiodoacetate, an inhibitor of glycolysis,disrupt chondrocyte metabolism and produces cartilage degeneration.In mice,injection of monoiodoacetate led to strong inhibitionof proteoglycan synthesis in the patella and in the medial part of tibial plateau.The loss of locomotor activity and the severity of cartilage lesions in patella were observed in rats injected with MIA.It was previously described, the im
Czech name
Exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy
Czech description
Práce popisuje problematiku exprese a produkce spinální cyklooxygenázy 1 a 2 v modelu experimentální osteoartritídy

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/NR9072" target="_blank" >NR9072: The role of neurotransmitters in mechanism of action of non-opioid analgesics</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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