Effects of Viscosupplementation on Tribological Behaviour of Articular Cartilage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU147499" target="_blank" >RIV/00216305:26210/22:PU147499 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/22:10157761 RIV/61989592:15110/22:73617694

Result on the web

<a href="https://www.mdpi.com/2075-4442/10/12/361" target="_blank" >https://www.mdpi.com/2075-4442/10/12/361</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/lubricants10120361" target="_blank" >10.3390/lubricants10120361</a>

Result language

angličtina

Original language name

Effects of Viscosupplementation on Tribological Behaviour of Articular Cartilage

Original language description

Osteoarthritis (OA) is one of the frequent conditions in the orthopaedic practice. The number of OA patients is increasing and the efficacy of the current treatment methods is relatively low in terms of slowing or even preventing of the disease progression. The current research suggests that the lubrication function of the cartilage depends on its articulating surfaces. These surfaces are characterized by extracellular matrices with a three-dimensional porous structure that ensures a proper lubrication regime to protect the surface against the wear. Viscosupplementation is one of the possible treatments to slow the OA progression. This therapeutic intervention is frequently used in the clinical practice for the knee osteoarthritis. Viscosupplementation can, to a certain extent, supplement the lubrication ability of the cartilage by doping the hyaluronic acid (HA) and thus delay the degradation. However, selection of a proper viscosupplement remains a challenge, both in terms of the correct evaluation of the HA properties and their interaction with different stages of the OA. The viscoupplements differ in their HA molecular weight that may influence the CoF development from both the short term and the long-term perspective. The aim of this study is to analyze the coefficient of friction (CoF) between the real surfaces of a bovine cartilage after applying viscosupplements. The experiments were conducted on a pin-on-plate tribometer with a real bovine cartilage to simulate the lubrication regimes of a human joint. The model joint was doped with 4 different commercially available viscosupplements with different molecular weights and cross-linking of the HA. The OA damage was simulated by using a model synovial fluid with a concentration that corresponds to an OA patient. A compression of the cartilage surface was observed during the experiment and the interstitial fluid drained away from the porous cartilage structure. This, in combination with a migrating contact area

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20301 - Mechanical engineering

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lubricants

ISSN

2075-4442

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

12

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

„“-„“

UT code for WoS article

000902587100001

EID of the result in the Scopus database

2-s2.0-85144836745