Impact of methamphetamine administered prenatally and in adulthood on cognitive functions of male rats tested in Morris water maze

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000560" target="_blank" >RIV/00216208:11120/08:00000560 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Impact of methamphetamine administered prenatally and in adulthood on cognitive functions of male rats tested in Morris water maze

Original language description

Studies showed that stimulant drugs that affect the monoaminergic system alter both behavioral and cognitive processes. The aim of the present study was to investigate the impact of prenatal and acute methamphetamine (MA) exposure on cognitive functions of adult male rats tested in Morris water maze (MWM). We tested adult male rats prenatally exposed to MA (5 mg/kg), saline or no injection. Half of the animals were injected daily with MA (1 mg/kg) after finishing the testing. All injections were administered subcutaneously. Three types of tests were used: (1) "Place navigation test" (Learning), (2) "Probe test" (Probe) and (3) "Retention memory test" (Memory). Our results showed that prenatal MA exposure did not affect the test of learning and the Probe test. In the test of memory prenatally MA-exposed rats had lower latencies than animals prenatally exposed to saline. Further, acute MA administration increased the speed of swimming in all rats regardless of prenatal drug exposure and the type of test and, however, the increase in the speed was significantly greater in rats prenatally exposed to MA than in rats without any prenatal exposure. In addition, acute MA application significantly prolonged trajectories in the Place navigation test. The present study thus demonstrates that: (1) Prenatal MA exposure does not affect learning in the MWM. (2) Prenatal MA exposure increases the sensitivity to acute drug injection. (3) Acute MA application impairs learning in the MWM.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GA305%2F06%2F0283" target="_blank" >GA305/06/0283: Sensitization induced by prenatal methamphetamine exposure in adult rats</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

62-70

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-59049101649