Gender differences in the effect of adult amphetamine on cognitive functions of rats prenatally exposed to methamphetamine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908432" target="_blank" >RIV/00216208:11120/14:43908432 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bbr.2014.04.040" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2014.04.040</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbr.2014.04.040" target="_blank" >10.1016/j.bbr.2014.04.040</a>

Result language
angličtina
Original language name
Gender differences in the effect of adult amphetamine on cognitive functions of rats prenatally exposed to methamphetamine
Original language description
Psychostimulants have been shown to affect brain regions involved in the process of learning and memory consolidation. It has been shown that females are more sensitive to the effects of drugs than males. The aim of our study was to investigate how prenatal methamphetamine (MA) exposure and application of amphetamine (AMP) in adulthood would affect spatial learning of adult female and male rats. Mothers of the tested offspring were exposed to injections of MA (5mg/kg) or saline (SA) throughout the entire gestation period. Cognitive functions of adult rats were evaluated in the Morris Water Maze (MWM) tests. Adult offspring were injected daily with AMP (5mg/kg) or SA through the period of MWM testing. Our data from the MWM tests demonstrates the following. Prenatal MA exposure did not change the learning ability of adult male and female rats. However, AMP administration to adult animals affected cognitive function in terms of exacerbation of spatial learning (increasing the latency to r
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/GA305%2F09%2F0126" target="_blank" >GA305/09/0126: Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats?</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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