Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00001261" target="_blank" >RIV/00216208:11120/08:00001261 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers

Original language description

Standard screening of melanoma patients is a useful tool for predicting outcome of patients, however, an instant methodology for exact detection of subclinical disease or monitoring treatment response is under investigation. Detection of circulating melanoma cells is, therefore, a possible novel promising staging method. However, inconsistent data on method sensitivity and on the predicted patient outcome has been shown repeatedly. Recently, a multimarker real-time RT-PCR methodology for quantificationof five melanoma markers Melan-A, gp 100, MAGE-3, MIA and tyrosinase was described by our group. In the current prospective trial, blood specimens of 65 patients with AJCC stage IIB-III cutaneous melanoma after surgery were periodically examined. In theabove group, 27 % of subjects relapsed during the study. Prior to the disease progression we could observe a statistically significant tumor marker elevation in previous 0 to 9 months in all patients with clinical relapse. MAGE-3 became t

Czech name

Včasná detekce progrese melanomu kvantitativní RT-PCR v reálném čase pomocí několika melanomových markerů

Czech description

Imunoterapie interferonem alfa je standardem léčby u rizikového maligního melanomu stádia IIB-III. Ve studii byla použita metoda multimarkerové RT-PCR v reálném čase pro kvantitativní detekci cirkulujících nádorových buněk u pacientů s melanomem. Pro sledování byly vybrány 4 markery - gp 100, MIA, tyrozináza a MAGE-3. V publikaci výsledky naznačují, že hladina cirkujících melanomových buněk úzce souvisí s úspěšností této léčby.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

<a href="/en/project/1A8243" target="_blank" >1A8243: Quantitative detection of circulating melanoma cells by real-time RT-PCR in patients treated for malignant melanoma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Keio Journal of Medicine

ISSN

0022-9717

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

1

Country of publishing house

JP - JAPAN

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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