Effect of methamphetamine exposure and cross-fostering on sensorimotor development of male and female rat pups

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00000490" target="_blank" >RIV/00216208:11120/09:00000490 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of methamphetamine exposure and cross-fostering on sensorimotor development of male and female rat pups

Original language description

The present study tested the hypothesis that cross-fostering influences the development of rat pups. Mothers were exposed daily to injection of methamphetamine (M) (5 mg/kg) or saline for 9 weeks: 3 weeks prior to impregnation, throughout gestation and lactation periods. Control females animals without any injections were used. On postnatal day (PD) 1, pups were cross-fostered so that each mother received four pups of her own and eight pups from the mothers with the other two treatments. Offspring weretested for sensorimotor development in preweaning period by using tests of: negative geotaxis, tail pull, righting reflexes, rotarod and bar-holding. Further: the pups were weighed daily. Our results showed that birth weight in prenatally M-exposed pupswas lower than in control or saline-exposed pups. Prenatally M-exposed pups gained less weight than control or saline-exposed pups regardless of postnatal treatment and sex. Further our data demonstrated that prenatal and postnatal M expo

Czech name

Vliv expozice metamfetaminu a cross-fosteringu na senzorimotorický vývoj samčích a samičích potkaních mláďat

Czech description

Prenatální expozice metamfetaminu negativně ovlivňuje mateřské chování a postnatální vývoj mláďat. Naše nejnovější poznatky ukazují, že zpoždění ve vývoji senzorimotorických funkcí je možné ovlivnit výchovou adoptivní kontrolní matkou.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Developmental Psychobiology

ISSN

0012-1630

e-ISSN

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Volume of the periodical

51

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

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UT code for WoS article

000262459400007

EID of the result in the Scopus database

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