Does cross-fostering modify the impairing effect of methamphetamine on postnatal development of rat pups?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000846" target="_blank" >RIV/00216208:11120/08:00000846 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Does cross-fostering modify the impairing effect of methamphetamine on postnatal development of rat pups?

Original language description

Our previous studies demonstrated that methamphetamine (MA) administered during gestation and lactation periods impairs maternal behavior as well as the postnatal development of rat pups. The present study tested the hypothesis that the cross-fostering influences the development of rat pups. Mothers were daily exposed to injection of MA (5 mg/kg) and saline for 9 weeks: three weeks prior to impregnation, throughout the entire gestation period and during lactation. As a control (C) females with no injections were used. On postnatal day (PD 1), pups were cross-fostered so that each mother received some of her own and some of the pups of mother with the other treatments. Pup's development and sensorimotor coordination was examined between PD 1 and PD 23.Following tests were used: tail pull (PD 10), righting reflex on surface (PD 12), righting reflex on mid-air (PD 17) and rotarod (PD 23). Our results showed that the birth weight in prenatally MA-exposed pups was lower than controls or sa

Czech name

Ovlivní "cross-fostering" negativní vliv metamfetaminu na postnatální vývoj potkaních mláďat?

Czech description

Prenatální expozice metamfetaminu negativně ovlivňuje mateřské chování a postnatální vývoj mláďat. Naše nejnovější poznatky ukazují, že zpoždění ve vývoji senzorimotorických funkcí je možné ovlivnit výchovou adoptivní kontrolní matkou.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/1A8610" target="_blank" >1A8610: Factors affecting healthy development of progeny of drug-abusing mothers</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

12

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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