The influence of methamphetamine on maternal behavior and development of the pups during the neonatal period

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913104" target="_blank" >RIV/00216208:11120/17:43913104 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ijdevneu.2017.03.005" target="_blank" >http://dx.doi.org/10.1016/j.ijdevneu.2017.03.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijdevneu.2017.03.005" target="_blank" >10.1016/j.ijdevneu.2017.03.005</a>

Result language

angličtina

Original language name

The influence of methamphetamine on maternal behavior and development of the pups during the neonatal period

Original language description

Since it enters breast milk, methamphetamine (MA) abuse during lactation can not only affect the quality of maternal behavior but also postnatal development of pups. The aim of the present study was to examine the effect of injected MA (5mg/kg) on maternal behavior of rats and the differences in postnatal development, during postnatal days (PD) 1-11, of pups when the pups were directly exposed (i.e., injected) to MA or received MA indirectly via breast milk. Maternal behavior was examined using observation test (PD 1-22) and pup retrieval test (PD 1-12). The following developmental tests were also used: surface righting reflex (PD 1-12), negative geotaxis (PD 9), mid-air righting reflex (PD 17), and the rotarod and beam-balance test (PD 23). The weight of the pups was recorded during the entire testing period and the day of eye opening was also recorded. MA-treated mothers groomed their pups less and returned the pups to the nest slower than control dams. The weight gain of pups indirectly exposed to MA was significantly slower. In addition, pups indirectly exposed to MA were slower on the surface righting reflex (on PD 1 and PD 2) and the negative geotaxis test. In females, indirect exposure to MA led to earlier eye opening compared to controls. At the end of lactation, males who received MA indirectly via breast milk performed worse on the balance beam test compared to males who received MA directly. However, direct exposure to MA improved performance on rotarod relative to controls. Our results suggest that indirect MA exposure, via breast milk, has a greater impact than direct MA exposure.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA14-03708S" target="_blank" >GA14-03708S: Determination of critical developmental period for methamphetamine effects in rats</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Developmental Neuroscience

ISSN

0736-5748

e-ISSN

—

Volume of the periodical

59

Issue of the periodical within the volume

June

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

37-46

UT code for WoS article

000402360300006

EID of the result in the Scopus database

2-s2.0-85016143492