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Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00000494" target="_blank" >RIV/00216208:11120/09:00000494 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378050:_____/09:00318330

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12

  • Original language description

    Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. It is often associated with development of allergic diseases such as asthma, rhinitis, and dermatitis. Production of IgE is influenced by genetic and environmental factors. In spite of progress in the study of heredity of atopy, the genetic mechanisms of IgE regulation have not yet been completely elucidated. The analysis of complex traits can benefit considerably from integration of human andmouse genetics.

  • Czech name

    Srovnávací genetika myši a člověka odhaluje nový lokus na Hsa8q12 kontrolující IgE

  • Czech description

    Byl nalezen nový lidský lokus kontrolující IgE v poloze 8q12, homologní k myšímu Lmr9, jenž vykazuje nápadné spojení se senzibilizací na inhalované alergeny. (LOD=2,21-2,42). Dále byly identifikovány další lokusy na 5., 7., 12. a 13. chromozomu vázané nainhalační alergii. Nález spojení na 8q12 ukazuje na prediktivní sílu myších modelů pro průzkum komplexního znaku u člověka.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2009

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Immunogenetics

  • ISSN

    0093-7711

  • e-ISSN

  • Volume of the periodical

    61

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    000263060800002

  • EID of the result in the Scopus database