A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00012716" target="_blank" >RIV/00216224:14110/05:00012716 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy

Original language description

Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopicresponses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T po

Czech name

Polymorfizmus v exonu genu pro CD14 receptor u mladých atopických pacientů v české populaci

Czech description

Gen kódující CD14 receptor je kandidátním genem pro atopii vzhledem ke své poloze na chromozomu 5q. V této studii byla nalezena asociace 1341G/T polymorfizmu v CD14 genu s atopickým fenotypem v české populaci.

Type

D - Article in proceedings

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/GP310%2F03%2FD193" target="_blank" >GP310/03/D193: The role of polymorphisms in the CD14 and TLR4 genes in atopic diseases in the Czech population</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

International Journal on Immunorehabilitation

ISBN

1562-3629

ISSN

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e-ISSN

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Number of pages

1

Pages from-to

74-74

Publisher name

III European Asthma Congress

Place of publication

Moscow, Russia

Event location

Athens, Greece

Event date

Jan 1, 2005

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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