Melatonin modulates hypoxia-induced changes of rat brain excitability

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002426" target="_blank" >RIV/00216208:11120/10:00002426 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/10:6500
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Melatonin modulates hypoxia-induced changes of rat brain excitability
Original language description
The aim of our study was to test the hypothesis, if melatonin pre-treatment (in dose of 100 mg/kg) can influence the changes of brain function after short-term hypoxia exposition (simulated altitude 9000 m) in young immature rats. Experiments were performed on freely moving 12-, 25- and 35-day-old male Wistar rats. One hour prior to hypoxia exposition, animals were pre-treated with melatonin and 24 hours after hypoxia cortical afterdischarges (ADs) were elicited by repeated stimulation of the right sensorimotor cortex. The duration of evoked ADs and shape of evoked graphoelements was monitored. Short-term exposure to hypoxic conditions resulted in significantly shorter ADs duration in 12-day-old rats after stimulations (except the 2(nd) one stimulation) compared to control group. Administration of melatonin prolonged the duration of ADs after all stimulations except the 1(st) one. Analysis of the duration ADs revealed no significant changes, either after the exposition to hypobaric hyp
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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