Nicotine reduces mortality of developing rats exposed to high-altitude hypoxia and partially suppresses the duration of cortical epileptic afterdischarges

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9204" target="_blank" >RIV/00216208:11110/11:9204 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.4149/gpb_2011_04_350" target="_blank" >http://dx.doi.org/10.4149/gpb_2011_04_350</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Nicotine reduces mortality of developing rats exposed to high-altitude hypoxia and partially suppresses the duration of cortical epileptic afterdischarges

Original language description

This study focused on the possible beneficial effects of nicotine against the high-altitude hypoxia (9000 m for one hour). 15 min prior to hypoxia exposition rats (12- and 35-day-old) were treated with nicotine. Next day electrodes have been implanted and the effects of nicotine and hypoxia (or both factors) on duration of afterdischarges (ADs) were tested. Administration of nicotine declined the hypoxia-induced mortality in 35-day-old animals. Nicotine pretreatment had no effect on ADs duration in 12-day-old pups, therefore brought about suppression of ADs in 35-day-old animals. Taken together, our data show that nicotine exhibits an anticonvulsant effect that is age-dependent.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/GP305%2F09%2FP136" target="_blank" >GP305/09/P136: Nicotine as a protective agent in neurodegenerative disorders - an ontogenetic study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

350-355

UT code for WoS article

000297775000003

EID of the result in the Scopus database

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