Local metabolism of glucocorticoids and its role in rat adjuvant arthritis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002476" target="_blank" >RIV/00216208:11120/10:00002476 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/10:00344044

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Local metabolism of glucocorticoids and its role in rat adjuvant arthritis

Original language description

11?-Hydroxysteroid dehydrogenase 1 (11HSD1) regulates local glucocorticoid activity and plays an important role in various diseases. Here, we studied whether arthritis modulates 11HSD1, what is the role of pro-inflammatory cytokines in this process and whether altered local metabolism of glucocorticoids may contribute to the feedback regulation of inflammation. Adjuvant arthritis increased synovial 11HSD1 mRNA and 11-reductase activity but treatments with tumor necrosis factor ? (TNF-?) and interleukin1? (IL-1?) antagonists etanercept and anakinra reduced 11HSD1 upregulation. Treatment with carbenoxolone, an 11HSD inhibitor, increased expression of TNF-?, cyclooxygenase 2, and osteopontin mRNA without any changes in the plasma levels of corticosterone. Similar changes were observed when arthritic rats were treated with RU486, an antagonist of GR. This study suggests that arthritis upregulates synovial 11HSD1, this upregulation is controlled by TNF-? and IL-1? a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA305%2F07%2F0328" target="_blank" >GA305/07/0328: The role of 11beta-hydroxysteroid dehydrogenase in glucocorticoid metabolism during immunomodulation</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular and Cellular Endocrinology

ISSN

0303-7207

e-ISSN

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Volume of the periodical

323

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

6

Pages from-to

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UT code for WoS article

000278791100004

EID of the result in the Scopus database

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