Upregulation of 11?-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003308" target="_blank" >RIV/00216208:11120/11:00003308 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jsbmb.2011.04.002" target="_blank" >http://dx.doi.org/10.1016/j.jsbmb.2011.04.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jsbmb.2011.04.002" target="_blank" >10.1016/j.jsbmb.2011.04.002</a>
Alternative languages
Result language
angličtina
Original language name
Upregulation of 11?-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat
Original language description
Glucocorticoids exert anti-inflammatory and immunomodulatory effects that may be regulated in part by the activities of the glucocorticoid-activating and -inactivating enzymes, 11?-hydroxysteroid dehydrogenase type 1 (11HSD1) and type 2 (11HSD2), respectively. Previous studies have demonstrated that inflammatory bowel diseases in humans and experimental animals upregulate 11HSD1 and downregulate 11HSD2. We investigated whether proinflammatory cytokines modulate colonic 11HSDs as well as whether lymphoidorgans exhibit any 11HSD response to inflammation. Colon tissue explants exposed to tumor necrosis factor ? exhibited an upregulation of 11HSD1 mRNA whereas interleukin 1? downregulated 11HSD2 mRNA. Experimental colitis induced by the intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid stimulated 11HSD1 activity not only in the colon but also in mesenteric lymph nodes and the spleen. Analysis of mRNA for 11HSD1 in colon-draining lymph nodes and the spleen showed that infla
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Steroid Biochemistry and Molecular Biology
ISSN
0960-0760
e-ISSN
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Volume of the periodical
126
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
19-25
UT code for WoS article
000292668100003
EID of the result in the Scopus database
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