Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice: A retrospective study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002605" target="_blank" >RIV/00216208:11120/10:00002605 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/10:00001073

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Antidepressant monotherapy and combination of antidepressants in the treatment of resistant depression in current clinical practice: A retrospective study

Original language description

The aim of this study was to compare efficacy of antidepressant monotherapies and combinations of antidepressants in the treatment of resistant patients in current clinical practice. Methods. We reviewed chart documents of resistant depressive inpatientstreated at least 4 weeks with a new treatment. Depressive symptoms and clinical status were assessed using Montgomery and Asberg Depression Rating Scale (MADRS), Beck Depression Inventory-Short Form and Clinical Global Impression at the baseline, week 2and in the end of treatment. Results. We identified 81 patients (27 with combinations and 51 with monotherapies) that were suitable for analyses. The combination group achieved higher reduction of MADRS score (14.6 vs 10.2 pts., p=0.02) and response rate (>= 50% reduction of MADRS, 67% vs 39%, p=0.03). Number needed to treat for response was 4. Conclusions. Based on our results, we suggest that combination of antidepressants might be more effective than monotherapy in clinical practice

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/NS10368" target="_blank" >NS10368: Prospective, randomized evaluation of efficacy of antidepressant monotherapy and antidepressant combination in the treatment of patients with resistant depression.</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Psychiatry in Clinical Practice

ISSN

1365-1501

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

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UT code for WoS article

000282811500013

EID of the result in the Scopus database

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