Antidepressant monotherapy compared with combinations of antidepressants in the treatment of resistant depressive patients: A randomized, open-label study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43896091" target="_blank" >RIV/00216208:11120/13:43896091 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/13:43914159
Result on the web
<a href="http://dx.doi.org/10.3109/13651501.2012.674533" target="_blank" >http://dx.doi.org/10.3109/13651501.2012.674533</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/13651501.2012.674533" target="_blank" >10.3109/13651501.2012.674533</a>

Result language
angličtina
Original language name
Antidepressant monotherapy compared with combinations of antidepressants in the treatment of resistant depressive patients: A randomized, open-label study
Original language description
This randomized, 6-week, open-label study compared efficacy of CAD and antidepressant monotherapies (ADM) that had been chosen according to clinical judgment of the attending psychiatrist. Methods. A total of 60 inpatients (intent-to-treat analysis) withdepressive disorder (> 1 unsuccessful antidepressant treatment) were randomly assigned to the interventions. The responders who completed the acute phase of study, were evaluated for relapse within 2 months of follow-up treatment. The primary outcome measure was change in the Montgomery-Asberg Depression Rating Scale (MADRS) and response was defined as a > 50% reduction of MADRS score. Results. Mean changes in total MADRS score from baseline to week 6 for patients in both treatment modalities were notdifferent (ADM = 13.2 - 8.6 points; CAD = 14.5 - 9.5 points; P = 0.58). The analysis of covariance performed for significantly higher value of imipramine equivalent dose in CAD group showed only a non-significant between-group difference
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Project
<a href="/en/project/NS10368" target="_blank" >NS10368: Prospective, randomized evaluation of efficacy of antidepressant monotherapy and antidepressant combination in the treatment of patients with resistant depression.</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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