Effects of 2-chloroadenosine on cortical epileptic afterdischarges in immature rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002876" target="_blank" >RIV/00216208:11120/10:00002876 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/10:00342602

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of 2-chloroadenosine on cortical epileptic afterdischarges in immature rats

Original language description

Adenosine may represent an endogenous anticonvulsant in the brain. This study focused on the possible anticonvulsant action of an adenosine agonist, 2-chloroadenosine, against cortical epileptic afterdischarges (ADs) in immature rats. Three age groups ofrat pups with implanted electrodes were studied: 12-, 18- and 25-days-old. The compound, 2-chloroadenosine, was injected after the first successful stimulation at doses of 1,4 or 10 mg/kg intraperitoneally, and stimulation at the same intensity was repeated three more times. Movements directly elicited by stimulation, as well as clonic seizures accompanying electroencephalography (EEG) ADs, were markedly suppressed in only the 18-day-old animals. The effects in the 12- and especially the 25-day-old rats were moderate. The duration of the ADs decreased in all three age groups with 2-chloroadenosine treatment, and the shortest AD duration was seen in the treated, 12-day-old rats. The AD suppression also lasted longer in this age group th

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/NR9184" target="_blank" >NR9184: Consequences of chronic intake of caffeine during early ontogeny on brain excitability</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacological Reports

ISSN

1734-1140

e-ISSN

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Volume of the periodical

62

Issue of the periodical within the volume

12

Country of publishing house

PL - POLAND

Number of pages

6

Pages from-to

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UT code for WoS article

000277174500006

EID of the result in the Scopus database

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